NDM-1 bakterija

jest10 je 27. jun 2013 ob 19:17 izjavil:

In kakšna je vrsta polja, ter kaj se z njim dogaja?

In kakšen je vpliv na dobre bakterije v črevesju? So te na skrivnosten način imune na to protibakterijsko antiferomagnetno polje, ali dobiš hudo drisko?

The competition for Fe is critical in the struggle between pathogen and host. Here we explore an antimicrobial approach that targets bacterial Fe metabolism by exploiting the chemical similarities between Fe and Ga. In in vitro studies, we found that low concentrations of Ga inhibit P. aeruginosa growth and prevent biofilm formation and that high levels kill planktonic bacteria and established biofilms. Although the available P. aeruginosa lung infection models are imperfect, we found corresponding effects in animal infections: Ga effectively cured acute lethal pneumonia, and early treatment reduced bacterial counts in an airway biofilm infection by approximately 1,000-fold. These data suggest that Ga’s ability to disrupt Fe metabolism in P. aeruginosa could be therapeutically useful in both acute and chronic infections.

A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.

Kako je z uporabo bakterijofagov proti takšnim odpornim bakterijam?

Okapi je 27. jun 2013 ob 20:15 izjavil:

In kakšen je vpliv na dobre bakterije v črevesju? So te na skrivnosten način imune na to protibakterijsko antiferomagnetno polje, ali dobiš hudo drisko?
O.

The antibacterial effects of gallium are extremely broad, since they stop all iron dependent bacteria and fungi in their tracks by immediately terminating their growth. Bacteria and fungi need iron for their reproduction, and gallium looks like iron to them. However, gallium (III) can not become gallium (II), while iron (III) can become iron (II). Consequently, bacteria cannot replicate when given gallium. Gallium (III) may be thought of as a "birth-control agent" (bacteriostatic) for bacteria. Since it does not kill them outright, they do not become resistant to gallium.

NOTE: Probiotic (beneficial intestinal) microorganisms including species of the genera Lactobacillus, Lactococcus, Bifidobacterium are not affected by the presence of gallium because they are not iron-dependent. Since probiotic bacteria are NOT adversely affected by gallium, this is why gallium does not cause intestinal problems in animals or people. It is harmless to beneficial intestinal bacteria.

Okapi je 18. jul 2013 ob 02:22 izjavil:

Ja, ko en šarlatan to na svoji spletni strani napiše, potem je sigurno res.

O.

Manganese is also used by L. plantarum in a pseudo-catalase to lower reactive oxygen levels. Because the chemistry by which manganese complexes protect the cells from oxygen damage is subverted by iron, these cells contain virtually no iron atoms; in contrast, a cell of Escherichia coli of comparable volume contains over one million iron atoms. Because of this L. plantarum cannot be used to produce active enzymes that require a heme complex such as true catalases.

Many lactobacilli do not require iron for growth and have an extremely high hydrogen peroxide tolerance.