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Znanstveniki uspeli pomladiti mišice
DarwiN ::
Researchers make old muscles young again in attempt to combat aging
The study looked at stem cells found inside muscle – which are responsible for repairing injury – to find out why the ability of muscles to regenerate declines with age. A dormant reservoir of stem cells is present inside every muscle, ready to be activated by exercise and injury to repair any damage. When needed, these cells divide into hundreds of new muscle fibres that repair the muscle. At the end of the repairing process some of these cells also replenish the pool of dormant stem cells so that the muscle retains the ability to repair itself again and again.
The researchers carried out a study on old mice and found the number of dormant stem cells present in the pool reduces with age, which could explain the decline in the muscle's ability to repair and regenerate as it gets older. When these old muscles were screened the team found high levels of FGF2, a protein that has the ability to stimulate cells to divide. While encouraging stem cells to divide and repair muscle is a normal and crucial process, they found that FGF2 could also awaken the dormant pool of stem cells even when they were not needed. The continued activation of dormant stem cells meant the pool was depleted over time, so when the muscle really needed stem cells to repair itself the muscle was unable to respond properly.
Following this finding, the researchers attempted to inhibit FGF2 in old muscles to prevent the stem cell pool from being kick-started into action unnecessarily. By administering a common FGF2 inhibitor drug they were able to inhibit the decline in the number of muscle stem cells in the mice.
Izjemno fascinanten in preprost proces, kajne?
In tako se bo začelo.. Mišice, kosti in koža najprej, desetletja zatem pa bolj kompleksni organi.
The study looked at stem cells found inside muscle – which are responsible for repairing injury – to find out why the ability of muscles to regenerate declines with age. A dormant reservoir of stem cells is present inside every muscle, ready to be activated by exercise and injury to repair any damage. When needed, these cells divide into hundreds of new muscle fibres that repair the muscle. At the end of the repairing process some of these cells also replenish the pool of dormant stem cells so that the muscle retains the ability to repair itself again and again.
The researchers carried out a study on old mice and found the number of dormant stem cells present in the pool reduces with age, which could explain the decline in the muscle's ability to repair and regenerate as it gets older. When these old muscles were screened the team found high levels of FGF2, a protein that has the ability to stimulate cells to divide. While encouraging stem cells to divide and repair muscle is a normal and crucial process, they found that FGF2 could also awaken the dormant pool of stem cells even when they were not needed. The continued activation of dormant stem cells meant the pool was depleted over time, so when the muscle really needed stem cells to repair itself the muscle was unable to respond properly.
Following this finding, the researchers attempted to inhibit FGF2 in old muscles to prevent the stem cell pool from being kick-started into action unnecessarily. By administering a common FGF2 inhibitor drug they were able to inhibit the decline in the number of muscle stem cells in the mice.
Izjemno fascinanten in preprost proces, kajne?
In tako se bo začelo.. Mišice, kosti in koža najprej, desetletja zatem pa bolj kompleksni organi.
You don't see faith healers working in hospitals
for the same reason you don't see psychics winning the lottery!
for the same reason you don't see psychics winning the lottery!
Yosh ::
Prehitro propadanje mišic oziroma zmanjšano število stem cell v mišicah ni edini faktor staranja,jih je mnogo več.
Vprašanje, kaj pravzaprav ta inhibicija povzroči v telesu; saj običajno je tako da nek protein npr. kot FGF2 ima tudi kakšne druge funkcije. Stvari niso tako preproste.
Vprašanje, kaj pravzaprav ta inhibicija povzroči v telesu; saj običajno je tako da nek protein npr. kot FGF2 ima tudi kakšne druge funkcije. Stvari niso tako preproste.
Share with others, your inner joy, goodness and beauty , and dont hurt them.
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