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NDM-1 bakterija

NDM-1 bakterija

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Okapi ::

In kakšen je vpliv na dobre bakterije v črevesju? So te na skrivnosten način imune na to protibakterijsko antiferomagnetno polje, ali dobiš hudo drisko?

O.

Double_J ::

jest10 je izjavil:

In kakšna je vrsta polja, ter kaj se z njim dogaja?


Antiferromagnetism @ Wikipedia

Dober primer je krom, ki je do 31celzija antiferomagneten. Kaj se z njim dogaja, to zaenkrat ne bi zaupal.

In kakšen je vpliv na dobre bakterije v črevesju? So te na skrivnosten način imune na to protibakterijsko antiferomagnetno polje, ali dobiš hudo drisko?


Kar sem jaz testiral ustreza infekcijam na koži. V notranjosti je pa precej drugače, drugačni so vsi vplivi. Kisik, svetloba itd...

Drugače pa imunski sistem teh dobrih bakterij ne bo kar napadel, za razliko od patogenih, ki jih bo pobil, ko bo dobil priložnost. Tu je ves štos.
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Okapi ::

Ves štos je nekje drugje, ampak več ti zaenkrat ne bi povedal. Bo precej bolje, če boš sam ugotovil.

O.

Vajenc ::

Bravo Double_J. Če ne drugega za vztrajnost (4 leta in 10k poskusov ni malo) "for a good cause". Če resnično pomaga nam ne govori preveč, dokler se ne zavaruješ s patentom ali poslom. Drugač ti bodo hijene ukradle idejo in jo kasneje prodajale za suho zlato.
Not only is there no God, but try finding a plumber on Sunday.
Woody Allen

Double_J ::

Vajenc je izjavil:

Bravo Double_J. Če ne drugega za vztrajnost (4 leta in 10k poskusov ni malo) "for a good cause". Če resnično pomaga nam ne govori preveč, dokler se ne zavaruješ s patentom ali poslom. Drugač ti bodo hijene ukradle idejo in jo kasneje prodajale za suho zlato.


Imam celo 2 stvari, ki delujeta. Osnova za drugi izum pa je...;)

Glitter @ Wikipedia
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Smurf ::

Kako pa si simuliral nadzarovano "naravno okolje". Kako si izvajal eksperimente (na katerih bakterijah si testiral, kake instrumente si pri tem uporabil, itd.) ter na podlagi cesa si sklepal o uspesnosti eksperimenta? Pac povej kaj vec o svojih metodah.

Double_J ::

Še en izum. Magnetit vržeš v glicerol pa še mal vode čez, zadeva sterilizira kar po zraku.

Čeprav vidim, da je še en folk nekaj dost podobnega počel. Samo nekam veliko čarajo za moje pojme, je pa to potditev da moje brute force metode delujejo.;)

http://www.hindawi.com/journals/chem/20...
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Double_J ::

The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity

http://www.jci.org/articles/view/30783

The competition for Fe is critical in the struggle between pathogen and host. Here we explore an antimicrobial approach that targets bacterial Fe metabolism by exploiting the chemical similarities between Fe and Ga. In in vitro studies, we found that low concentrations of Ga inhibit P. aeruginosa growth and prevent biofilm formation and that high levels kill planktonic bacteria and established biofilms. Although the available P. aeruginosa lung infection models are imperfect, we found corresponding effects in animal infections: Ga effectively cured acute lethal pneumonia, and early treatment reduced bacterial counts in an airway biofilm infection by approximately 1,000-fold. These data suggest that Ga’s ability to disrupt Fe metabolism in P. aeruginosa could be therapeutically useful in both acute and chronic infections.


Preberite dobro tale članek. Dvomim da pri nas to kdo uporablja, ljudje pač umrejo...
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Double_J ::

Če gledaš tako, potem smo že v riti. Zdravljenje z linezolidom (recimo, da je še malo boljši kot vankomicin) stane precej tisoč evrov na osebo.

Problem obeh pa je, da nimata skoraj nobenega vpliva na gram-negativne vrste bakterij, kot je naprimer Klebsiella pneumoniae, ki je NDM-1 dovzetna bakterija.


S temle galijem so fentali gram-negativno bakterijo, proti kateri je MRSA precej neumnejša, kar se tiče biofilma in organizacije. Meni se zdi Pseudomonas aeruginosa še najbolj inteligentna od vseh bakterij. Sej zato pa tvori te biofilme kar povsod, na živalih, na rastlinah, na neživi naravi, v vesolju. Okapi se bo verjetno posmehoval tem raziskovalcem, realnost je pa takšna, da če se boš pri čem takem držal samo nasvetov iz našega kliničnega centra, boš končal pomoje na žalah.

On 29 April 2013, French scientists, funded by NASA, reported that, during spaceflight inside the International Space Station, P. aeruginosa bacteria seem to adapt to the microgravity and the biofilms formed during spaceflight exhibited a column-and-canopy structure that has "not been observed on Earth".[4]


Pseudomonas aeruginosa @ Wikipedia
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Double_J ::

Samo tolk, da vemo... da take zadeve pobijajo kar vse po vrsti, tudi omenjeno NDM-1 dovzetno bakterijo.

A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.


http://www.google.com/patents/EP2427061...
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gendale ::

Kako je z uporabo bakterijofagov proti takšnim odpornim bakterijam?
seznam zanč moderatorjev in razlogov da so zanč
http://pastebin.com/QiWny5dV
gor je mavrik apple uporabniček (mali možgani in mali penis)

Double_J ::

Kako je z uporabo bakterijofagov proti takšnim odpornim bakterijam?


Jaz imam raje bolj čiste pristope. Pa to je dovoljeno v Rusiji, na zahodu pa ne.

Phage therapy @ Wikipedia


Okapi je izjavil:

In kakšen je vpliv na dobre bakterije v črevesju? So te na skrivnosten način imune na to protibakterijsko antiferomagnetno polje, ali dobiš hudo drisko?
O.




The antibacterial effects of gallium are extremely broad, since they stop all iron dependent bacteria and fungi in their tracks by immediately terminating their growth. Bacteria and fungi need iron for their reproduction, and gallium looks like iron to them. However, gallium (III) can not become gallium (II), while iron (III) can become iron (II). Consequently, bacteria cannot replicate when given gallium. Gallium (III) may be thought of as a "birth-control agent" (bacteriostatic) for bacteria. Since it does not kill them outright, they do not become resistant to gallium.

NOTE: Probiotic (beneficial intestinal) microorganisms including species of the genera Lactobacillus, Lactococcus, Bifidobacterium are not affected by the presence of gallium because they are not iron-dependent. Since probiotic bacteria are NOT adversely affected by gallium, this is why gallium does not cause intestinal problems in animals or people. It is harmless to beneficial intestinal bacteria.


Hja Okapi, to je pa le treba vedeti, ko se igramo z raznimi kovinami.;)
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Zgodovina sprememb…

  • spremenil: Double_J ()

Okapi ::

Ja, ko en šarlatan to na svoji spletni strani napiše, potem je sigurno res.;((

O.

Double_J ::

Okapi je izjavil:

Ja, ko en šarlatan to na svoji spletni strani napiše, potem je sigurno res.;((

O.


No pa poglejmo, kaj piše za lactobacilluse...

Manganese is also used by L. plantarum in a pseudo-catalase to lower reactive oxygen levels. Because the chemistry by which manganese complexes protect the cells from oxygen damage is subverted by iron, these cells contain virtually no iron atoms; in contrast, a cell of Escherichia coli of comparable volume contains over one million iron atoms. Because of this L. plantarum cannot be used to produce active enzymes that require a heme complex such as true catalases.

Lactobacillus plantarum @ Wikipedia

Many lactobacilli do not require iron for growth and have an extremely high hydrogen peroxide tolerance.

Lactobacillus @ Wikipedia
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